The SOS global response SIGNALS for Oslo, Norway
The modern social science wars expressed by the atoms and proteins of humanoid participants —> protein actors in the Theater of Intellectual War.
RD-blog-number-2192 by Herb Zinser
SOS Response à the living EARTH cell and its geography surface with its living cities and institutions ….often reflects the INTERNAL biology cell wars . Below, are genetics/ molecular cell biology descriptions from university and corporate labs. Using that data we can see some expressions of cell anger ………..those expressions use the EARTH humans as vehicles/ as messengers/ as actors ……that perform EXTERNAL displays of anger …following Nature’s cellular war instructions.
SOS response – Wikipedia, the free encyclopedia
en.wikipedia.org/wiki/SOS_response
The SOS response is a global response to DNA damage in which the cell cycle is arrested and DNA repair and mutagenesis are induced. The system involves …
Discovery – Mechanism – Antibiotic resistance – Genotoxicity Testing
The SOS response has been proposed as a model for bacterial evolution of certain types of antibiotic resistance.[1]
The SOS response is a global response to DNA damage in which the cell cycle is arrested and DNA repair and mutagenesis are induced. The system involves the RecA protein (Rad51 in eukaryotes). The RecA protein, stimulated by single-stranded DNA, is involved in the inactivation of the LexA repressor thereby inducing the response. It is an error-prone repair system.
àTranslation of the EARH LAB social science illness of cities and their citizen nonsense
Word SIGNAL: SOS response is a global response
Keywords: SOS ……………….bal
Example: Sammy SOSA …………….bal –> Base Bal(l) and Baltimore sports
Samuel Peralta “Sammy” Sosa (born November 12, 1968) is a Dominican former professional baseball right fielder. Sosa played with four Major League Baseball teams over his career which spanned from 1989-2007.
Sosa played with four Major League Baseball
Sos layer with four Major Nitrogenous Bases
Sos box …. in the operator region for those genes applied genetics
SOSA in the DNA nucleotide batter’s box
| Right fielder | |
| Born: November 12, 1968 (age 43) San Pedro de Macorís, Dominican Republic | |
| Batted: Right | Threw: Right |
| MLB debut | |
|---|---|
| June 16, 1989 for the Texas Rangers | |
Major league career
- 2.1 Texas Rangers, Chicago White Sox (1989–1991)
- 2.2 Chicago Cubs (1992–2004)
- 2.3 Baltimore Orioles and year off (2005–2006)
- 2.4 Recent years (2007–2009)
Mechanism
During normal growth, the SOS genes are negatively regulated by LexA repressor protein dimers. Under normal conditions, LexA binds to a 20-bp consensus sequence (the SOS box) in the operator region for those genes. Some of these SOS genes are expressed at certain levels even in the repressed state, according to the affinity of LexA for their SOS box. Activation of the SOS genes occurs after DNA damage by the accumulation of single stranded (ssDNA) regions generated at replication forks, where DNA polymerase is blocked. RecA forms a filament around these ssDNA regions in an ATP-dependent fashion, and becomes activated. The activated form of RecA interacts with the LexA repressor to facilitate the LexA repressor’s self-cleavage from the operator.[3]
àTranslation words: protein dimmers ….. with the proteins of physics professors and the theory of 11-dimensions of DIMER string theory ……..with Margaret Mead nuclear family anthropology LAB dimer specimen ….Jessie Dimmick….. who received an 11-year prison sentence of behalf of atomic social engineering experiments ….and is testing the secret CLOSED and MYOPIC communications of universities.
à Translation of the above regarding Runway 26
| Word SIGNAL: LexA represor proteins …..SOS box …polymerase…. RecA Keywords: LexA …………………….SOS ……………erase ……RecA Example: Lexington Airport…..SOS emergency….erase COMAIR… wRECk Airplane |
SOS box à the airplane is like a rectangular box of aluminum metal,etc
Above, INTERNAL ……. DNA structure, flowcharts and DNA alphabet runways
Below, the Mirror of Miroslav RADMAN who discovered SOS repsonse.
Analysis of the cockpit voice recorder (CVR) indicated the aircraft was cleared to take off from Runway 22, a 7,003 feet (2,135 m) strip used by most airline traffic at Lexington.[5] Instead, after confirming “Runway two-two”, Captain Jeffrey Clay taxied onto Runway 26,
Approximate paths at Blue Grass Airport (picture before airport construction done weeks before the crash):
Desired path via Runway 22
Actual path via Runway 26, ending at approximate crash site.
X marks the closed taxiway
Analysis of the LexA and the English alphabet …the LEXICON of Runway 26 letters. Thus the TRUE NATURE of the communications mix-up at the Lexington Airport ………. was Nature’s way of getting out a signal about 26 letters of Lex A = Lexicon Alpabet words . Hence, Nature’s military brain cells managed to push button in the brains of the airport and airline personnel. Thus …as William Shakespeare stated
” The WORLD is a stage and we are the biochemistry players”.
Below words: pool of LexA
Translate: Computer Earth system 370 with I/O port and terminal à air.PORT TERMINAL and the data record buffer pool of Lexington, Americans..
Once the pool of LexA decreases, repression of the SOS genes goes down according to the level of LexA affinity for the SOS boxes. Operators that bind LexA weakly are the first to be fully expressed. In this way LexA can sequentially activate different mechanisms of repair. Genes having a weak SOS box (such as lexA, recA, uvrA, uvrB, and uvrD) are fully induced in response to even weak SOS-inducing treatments. Thus the first SOS repair mechanism to be induced is nucleotide excision repair (NER), whose aim is to fix DNA damage without commitment to a full-fledged SOS response.
If, however, NER does not suffice to fix the damage, the LexA concentration is further reduced, so the expression of genes with stronger LexA boxes (such as sulA, umuD, umuC – these are expressed late) is induced. SulA stops cell division by binding to FtsZ, the initiating protein in this process. This causes filamentation, and the induction of UmuDC-dependent mutagenic repair. As a result of these properties, some genes may be partially induced in response to even endogenous levels of DNA damage, while other genes appear to be induced only when high or persistent DNA damage is present in the cell.
Antibiotic resistance
Recent research has shown that the SOS pathway may be essential in the acquisition of bacterial mutations which lead to resistance to some antibiotic drugs.[4] The increased rate of mutation during the SOS response is caused by three low-fidelity DNA polymerases: Pol II, Pol IV and Pol V.[4] Researchers are now targeting these proteins with the aim of creating drugs that prevent SOS repair. By doing so, the time needed for pathogenic bacteria to evolve antibiotic resistance could be extended, and thus improve the long term viability of some antibiotic drugs.[5]
àBelow ..city testing … Baltimore region
Genotoxicity Testing –>
Population: 620,961 (2010)
The Baltimore Sun | Breaking news, sports, weather and traffic in … www.baltimoresun.com/Cached – Similar
News, business, sports, arts, lifestyle, opinion, archives, classifieds, food, travel and subscription and advertising information for the Baltimore region can be …
Baltimore
Baltimore is the largest city in the U.S. state of Maryland. It is located in the central area of the state along the tidal portion of the Patapsco River, an arm of the Chesapeake Bay. Wikipedia
Overview of the use of the SOS response for genotoxicity testing
àTranslation of below ….
Escherichia coli à E coli
Escherichia = E + sch + er = Education school error
Different classes –> the school classroom shootings .
Timeline of School Shootings – US News and World Report
Feb 15, 2008 – Clarification: An earlier version of this timeline omitted several significant shootings that have taken place at colleges and other schools since …
- School shooting – Wikipedia, the free encyclopediaen.wikipedia.org/wiki/School_shootingCached – SimilarA school shooting is an incident in which gun violence occurs at an educational institution. ….. Timeline of School Shootings – US News and World Report”.
- Timeline: US shooting sprees – History of school shootings «
Thus the E coli shootings …….. like Virginia TECH English department and the grammer / high school shootings
In Escherichia coli, different classes of DNA-damaging agents can initiate the SOS response, as described above. Taking advantage of an operon fusion placing the lac operon (responsible for producing beta-galactosidase, a protein which degrades lactose) under the control of an SOS-related protein, a simple colorimetric assay for genotoxicity is possible. A lactose analog is added which to the bacteria, which is degraded by beta-galactosidase, producing a colored compound which can be measured quantitatively through spectrophotometry). The degree of color development is an indirect measure of the beta-galactosidase produced, which itself is directly related to the amount of DNA damage.
àAbove…lac operon at Lac La Belle, Oconomowoc, Wisconsin region with Mark and Gloria Totzke.
àAbove spectrophotometry with the tatoo optical signal of seemen (seaman) Richard Speck (year 1966) in the Chicago spectrum murders
The E. coli are further modified in order to have a number of mutations including a uvrA mutation which renders the strain deficient in excision repair, increasing the response to certain DNA-damaging agents, as well as an rfa mutation, which renders the bacteria lipopolysaccharide-deficient, allowing better diffusion of certain chemicals into the cell in order to induce the SOS response. [6] Commercial kits which measures the primary response of the E. coli cell to genetic damage are available and may be highly correlated with the Ames Test for certain materials.[7]
Thus the SOS = S + OS –> Shootings OSLO ……ought pay attention to Nature’s message EVENT at UTOEYA.